Research Interests

  • Inhibitors of ergosterol and cholesterol biosynthesis as new drug candidates
  • Development of novel modulators of epigenetic target enzymes (kinases, sirtuins, …)
  • Development of novel modulators of cation channels (TPCs, TRPMLs)
  • Natural products chemistry (synthesis, biological activities)
  • High-end GC-MS analytics (method development, applications in biomedicine and ecology)

Short CV

  • Studied pharmacy at the LMU Munich
  • 1986 PhD in Pharmaceutical Chemistry, LMU Munich
  • 1986-1987 Postdoctoral Researcher at the Department of Organic Chemistry, University of Geneve/Switzerland
  • 1991 Habilitation, University of Marburg
  • 1992-1997 C3 Professor, University of Braunschweig
  • Since 1997 C4 Professor for Pharmaceutical Chemistry, LMU Munich

Key publications

  • M. Müller, S. Gerndt, Y.-K. Chao, T. Zisis, O. N. P. Nguyen, A. Gerwien, N. Urban, C. Müller, F. A. Gegenfurtner, F. Geisslinger, C. Ortler, C.-C. Chen, S. Zahler, M. Biel, M. Schaefer, C. Grimm, F. Bracher, A. M. Vollmar, K. Bartel: Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth. Cell Chem. Biol. 28, 1119-1131.e27 (2021)
  • C. Glas, J. C. B. Dietschreit, N. Wössner, L. Urban, E. Ghazy, W. Sippl, M. Jung, C. Ochsenfeld, F. Bracher: Identification of the subtype-selective Sirt5 inhibitor balsalazide through systematic SAR analysis and rationalization via theoretical investigations. Eur. J. Med. Chem. 206, 112676 (2020)
  • R. Schütz, M. Meixner, I. Antes, F. Bracher: A modular approach to the bisbenzylisoquinoline alkaloids tetrandrine and isotetrandrine. Org. Biomol. Chem. 18, 3047-3068 (2020)
  • C. Müller, J. Junker, F. Bracher, M. Giera: A gas chromatography – mass spectrometry based whole cell screening assay for target identification in distal cholesterol biosynthesis. Nature Protocols 14, 2546-2570 (2019)
  • C.-C. Chen, M. Keller, M. Heß, R. Schiffmann, N. Urban, A. Wolfgardt, M. Schaefer, F. Bracher, M. Biel, C. Wahl-Schott, C. Grimm: A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV. Nature Communications 5: 4681, (2014)